Endocrinology Daily Report: 01/19/2024

A phase I, multicentre clinical trial (Poscal Study) investigated the effect of monthly calcifediol treatments for vitamin D deficiency in 101 young adults with no associated comorbidities (1). The study found that 82% of the subjects (79/96) achieved 25(OH)D levels within the target range (20-60 ng/mL) by the end of the treatment phase. At the end of the follow-up phase, 89% of participants maintained vitamin D levels of >20 ng/mL with calcifediol, versus 49% with placebo (p < 0.001). No clinically relevant changes in bone metabolism parameters or toxic 25(OH)D levels were observed, and no serious adverse events were reported throughout the study.

Reference

Guerra López P, Urroz Elizalde M, Vega-Gil N, Sánchez Santiago B, Zorrilla Martínez I, Jiménez-Mercado M, Jódar E, Landeta Manzano A, Campo Hoyos C, Frías Iniesta J. Efficacy and Safety of Calcifediol in Young Adults with Vitamin D Deficiency: A Phase I, Multicentre, Clinical Trial-POSCAL Study. Nutrients. 2024 Jan 19;16(2):306. doi: 10.3390/nu16020306. PMID: 38276544.