Ophthalmology Daily Report: 01/26/2024

A phase I/II randomized, double-masked, placebo-controlled study investigated the effect of processed amniotic fluid (pAF) drops in 61 participants after PRK and found a statistically significant difference in uncorrected distance visual acuity at 1 month post-PRK in favor of the pAF group, with a suggestive difference in corneal irregularity measurement at the same time point (1). There were no significant differences in uncorrected distance visual acuity or corneal irregularity measurement at 3, 6, and 12 months, indicating a mild visual advantage of pAF at 1 month post-PRK with no late adverse events, proving the intervention safe at 1 year.

Reference

Kirschenbaum MD, Hu KS, Ip CS, Lin A, Pierce J, Holubkov R, Jensen H, Mifflin MD. One-Year Results of a Phase I/II Randomized, Double-Masked, Placebo-Controlled Study of Processed Amniotic Fluid Drops After PRK. Cornea. 2024 Jan 26. doi: 10.1097/ICO.0000000000003474. Epub ahead of print. PMID: 38277050.