Jan 2nd, 2024

A prospective cohort study aimed to examine the symptoms of Postural Orthostatic Tachycardia Syndrome (POTS) and their phenotypes (1). The study involved a total of 378 patients suffering from POTS. The results of this research indicated that there were no significant differences in the presentation of symptoms among the various POTS phenotypes. This finding holds considerable clinical significance as it suggests that the phenotypes of POTS cannot be effectively distinguished based solely on symptomatic presentation. This implies that more rigorous testing methods are necessary for accurate phenotyping of POTS. The lack of variability in symptom presentation across different phenotypes highlights the complexity and the need for advanced diagnostic tools in managing POTS.

1. Angeli AM, Salonen BR, Ganesh R, Hurt RT, Abdalrhim A, Mueller M, et al. Symptom presentation by phenotype of postural orthostatic tachycardia syndrome. Sci Rep. 2024;14(1):205.